Human liver hepatocytes are an in vitro tool for studying liver physiology. Due to their retention of tissue properties, especially drug detoxification, their use has notably increased in pharmacological and toxicological studies. Evaluating drug toxicity and the resultant metabolite on primary human hepatocytes has facilitated effortless and high-throughput screening of multiple drug candidates simultaneously.
They are considered the gold standard for preclinical drug validation assays. They have also augmented our understanding of liver disorders. However, they have limited proliferative capacity in vitro. Their applications have surged their in vitro use, prompting scientists to develop strategies for better hepatocyte culture.
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