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DRIVEN BY THE INCREASED ADOPTION AND RISING UNMET NEED ASSOCIATED WITH PARENTERAL DRUGS, INDUSTRY STAKEHOLDERS HAVE MADE SIGNIFICANT INVESTMENTS TOWARDS THE DEVELOPMENT OF ORALLY ADMINISTERED PROTEIN AND PEPTIDE THERAPEUTICS
Over the years, advances in recombinant DNA technology and ex vivo synthesis of biomolecules have led to the development and (in some cases) approval of several protein / peptide-based therapeutics.
Considering the therapeutic advantages associated with proteins and peptides, this field has witnessed significant activity; researchers are actively evaluating orally bioavailable interventions. However, owing to their inherently complex structure and comparatively low stability (in in vivo conditions), proteins / peptides are predominantly administered parenterally.
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