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Hepatocytes are the main cellular population of the liver. These binucleated cells carry out key functions of the liver, such as nutrient metabolism, xenobiotic detoxification, cholesterol synthesis, bile production, etc. Due to their role in detoxification, these cells are frequently used to evaluate drug metabolism and toxicity. They have found applications in research with respect to exploring liver regeneration, pathology of viral infections, modeling of liver diseases, and nutrient metabolism.
The therapeutic applications of primary human liver hepatocytes include transplantation. The infusion of hepatocytes to regenerate the liver instead of a whole liver is under investigation. Additionally, formation of artificial liver by bioprinting and designing of bioartificial liver containing hepatocytes are being streamlined for clinical translation. It can save lives of people in need of liver transplants. The shortage of healthy donors and subsequent mortality risk can be avoided with normal liver transplant. For accelerated drug discovery process swine liver hepatocytes are used in research due to easy availability and identical characteristics to that of human physiology.
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